Just out in today's Science: "Technological challenges and milestones for writing genomes." One of a pair of papers I've been working on with the GP-write consortium, both of which are asking the question: what, exactly, do we need in order to go from engineering millions of base-pairs of DNA in bacteria and yeast to the billions of base-pairs in complex organisms like mammals, plants, and people?
This paper focuses on the DNA-wrangling side of the problem, while its complement (on arXiv and under revision) focuses on the informational and coordination side of the problem. Both need to be addressed, and the complexity---while daunting---is tractable. Take a read-through and see our take on the matter!
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